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KMID : 0043320100330010061
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.61 ~ p.65
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Synthesis and Microbiological Evaluation of Honokiol Derivatives as New Antimicrobial Agents
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Park Deok-Hoon
Lee Ji-Young
Lee Jong-Sung
Kim Young-Soo
Hwang Wang-Taek
Park Jun-Ho
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Abstract
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Honokiol, a major phenolic constituent of Magnolia sp., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-derivatives (honokiol-acetate, honokiol-succinic acid, honokiol-glycerol, honokiol-glycine, honokiol-glucose and honokiol-mannose) were synthesized and their solubility and antimicrobial activities were investigated. Among the tested compounds, honokiol-glycine showed improved water solubility and antibacterial activities against E. coli and P. aeruginosa when compared to honokiol.
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KEYWORD
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Honokiol derivatives, Anti-bacterial, Escherichia coli, Pseudomonas aeruginosa
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